Neuronal network synchronization and limbic seizures

Decreased neuronal synchronization during experimental seizures.

Synchronization between CA1 pyramidal neurons was studied using dual-cell patch-clamp techniques simultaneous with an extracellular measurement of network activity. We explored various linear and nonlinear methods to detect weak synchronization in this network, using cross-correlation, mutual information in one and two dimensions, and phase correlation in both broad and narrow band. The linear ...

Cortical deactivation induced by subcortical network dysfunction in limbic seizures.

Normal human consciousness may be impaired by two possible routes: direct reduced function in widespread cortical regions or indirect disruption of subcortical activating systems. The route through which temporal lobe limbic seizures impair consciousness is not known. We recently developed an animal model that, like human limbic seizures, exhibits neocortical deactivation including cortical slo...

Hyper-Synchronization, De-Synchronization, Synchronization and Seizures

Cholinergic Neurotransmission In Partial Limbic Seizures

Cholinergic Neurotransmission in Partial Limbic Seizures. Geoffrey Liu, Joshua E. Motelow, Wei Li, Qiong Zhan, Asht M. Mishra, Robert N. S. Sachdev, Abhijeet Gummadavelli, Zaina Zayyad, Hyun Seung Lee, Victoria Chu, John P. Andrews, Dario J. Englot, Peter Herman, Basavaraju G. Sanganahalli, Fahmeed Hyder, Hal Blumenfeld. Partial limbic seizures impair consciousness, but the mechanism of impairm...

Repetitive low-frequency stimulation reduces epileptiform synchronization in limbic neuronal networks.

Deep-brain electrical or transcranial magnetic stimulation may represent a therapeutic tool for controlling seizures in patients presenting with epileptic disorders resistant to antiepileptic drugs. In keeping with this clinical evidence, we have reported that repetitive electrical stimuli delivered at approximately 1 Hz in mouse hippocampus-entorhinal cortex (EC) slices depress the EC ability ...